ChromSword Auto | On-line method development

ChromSword® Auto stands for AUTOMATION

ChromSword® Auto can either be used off-line as stand alone software for computer assisted HPLC method development (see ChromSword® Off-line), or when fully integrated into an HPLC system, it creates a powerful specialized method development system capable of developing completely new methods or existing ones fully automatically.

See more and do more

FULLY AUTOMATIC Development of new or improvement of existing HPLC methods
Development of ASSAY and/or
RELATED SUBSTANCES/IMPURITIES methods
Development of RELATED SUBSTANCES/IMPURITIES
methods with impurities < 0.05 area%
ChromSword® Auto supports CHIRAL HPLC method development

ChromSword^®Auto - translates into EFFICIENCY and TIME SAVINGS

Rapid development of new initial methods
1-2 hours/sample development time
Optimization of separation of only target compounds
1-48 hours/sample
Sample study for impurity profiling. Separation of the maximum number of compounds
6-48 hours/sample
Screening columns and solvents/pH
1-3 hours/column/solvent/sample
Generation of an analytical development project report
1-5 min/project

ChromSword® Auto hard and software integration

Agilent HPLC	1100, 1200, 1200RR			1200 Method Development
ChromSword® Auto Version*	CSA 3.5			NEW: CSA 3.5 Rev 810.2008
Agilent Software	ChemStation® 16 bit versions A 09.01 and higher ChemStation® 32 bit versions B.01 and higher EZChrom Elite® HPLC software (stand alone or client server)			ChemStation® 32 bit version B.04
Waters Software	Millenium Empower/Empower II (stand alone and client server configuration)			* Support of Agilent MSD and 3rd party detectors via Agilent A/D converter
Waters HPLC	Alliance	UPLC Acquity
ChromSword® Auto Version	CSA 3.5	NEW: CSA 3.5 (WU)
Waters Software	Millenium® Empower®/Empower® II (stand alone and client server configuration)
Hitachi HPLC	LaChrom		LaChrom®Elite, LaChrom®Ultra
ChromSword® Auto Version	3.5
Hitachi Software	HSM®
Agilent Software			EZChrom Elite®
Berger SFC	SFC
ChromSword® Auto Version	4.0 Pro
Agilent Software	ChemStation®

ChromSword® Auto - supports column and solvent screening

all Agilent and Waters internal column and solvent switching valves
external column switching valves, e.g. Chiralizer Spiderling or VICI Valco Column Switching Valves
external solvent switching valves, e.g. VICI Valco 10-positions Valve

column and solvent screening with ChromSwordAuto

ChromSword® Auto - artificial intelligence

Artificial intelligence enables the software to control the process and to take the necessary decisions during the automatic method development procedure. It simulates the actions and decisions of a human developer.

ChromSword® Auto - intelligent peak tracking

The easiest way to solve the task of peak assignment and peak tracking unequivocally is to perform the experimental method development with single pure substances (standards) of the compounds to be separated. However, one often faces the situation that a suitable standard is not available for all compounds. An example is the analysis of impurities in a product, where usually only a few (if any) of the impurities are available as pure substances.

ChromSword® Auto is equipped with the revolutionary Intelligent Peak Tracking function, which ensures reliable peak assignment even in compound mixtures, without the necessity to use spectral data. No standards are necessary, regardless of how many compounds are present in the mixture. By recording and tracking the peaks that emerge under different chromatographic conditions, the system ensures that all peaks are clearly isolated and optimized.

ChromSword® Auto - anyone can do it

Since not much chromatography background is necessary to operate ChromSword®Auto, chromatography novices can now easily perform HPLC method development. However, ChromSword®Auto is not just for novices. Because ChromSword®Auto ensures drastic savings in the method development process time and since experience has shown that this software can frequently solve even the “unsolvable” separation problem, even experts will benefit from it.